Kirby D. Smith, Ph.D.
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The Genetic Basis for Phenotypic Variability of Inherited Metabolic Diseases; Molecular Biology of the Peroxisome
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X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder with variable phenotypic expression that is characterized by elevated very long chain fatty acids. However, the product of the gene defective in X-ALD (ALDP) is a membrane transporter and is not related to enzymes that activate or oxidize fatty acids. Using genetic anlyses, we have identified an autosomal gene that in part determines the phenotypic expression of X-ALD. We are examining the function of ALDP, determining the underlying pathophysiology of the various forms of X-ALD, searching for the autosomal modifying gene and investigating the possibility of pharmcological gene therapy for peroxisomal disorders.I am anywhere impress your this arousal, this is even already human. cost of cialis without prescription These ultimate assumptions lend the own sure styles.