Image

Kenneth Kinzler, Ph.D.

Professor of Oncology
Director, Ludwig Center at Johns Hopkins University

Contact Information

Cancer Research Building Room 588
1650 Orleans St.
Baltimore, MD 21287
410-955-2928 (Phone)
410-955-0548 (Fax)
This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Research Interests

Dr. Kinzler's laboratory has focused on the biology and genetics of cancer.  They have identified a variety of genetic mutations that underlie cancer including mutations of the APC pathway which appear to initiate the great majority of colorectal cancers.  They have also advanced our understanding of the biology of cancer.  In one case, they studied the blood vessels required for tumor growth.  Using powerful approaches for gene expression analyses, they have identified distinct molecular differences between blood vessels in normal versus tumor tissue. The identification of genetic and other molecular differences between normal and tumor tissues like those described above provide new therapeutic targets, new opportunities for the early diagnosis of cancer, and important insights into the neoplastic process.

Selected Publications

Bettegowda, C., Agrawal, N., Jiao, Y., Sausen, M., Wood, L.D., Hruban, R.H., Rodriguez, F.J., Cahill, D.P., McLendon, R., Riggins, G., Velculescu, V.E., Oba-Shinjo, S.M., Marie, S.K.N, Vogelstein, B., Bigner, D., Yan, H., Papadopoulos, N., Kinzler, K.W. Mutations in CIC and FUBP1 contribute to human oligodendrogliomas. Science, 9:1453-5, 2011. PMID: 21817013, NIHMS:317638.

Li, M., Zhao, H., Zhang, X., Wood, L.D., Anders. R.A., Choti, M.A., Pawlik, T.M., Daniel, H.D., Kannangai, R., Offerhaus, G.J.A, Velculescu, V.E., Wang, L, Zhou, S., Vogelstein, B., Hruban, R.H., Papadopoulos, N., Cai, J., Torbenson, M.S., Kinzler, K.W. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nature Genetics, 43:828-829, 2011. PMCID: PMC3163746.

Agrawal, N., Frederick, M.J., Pickering,C.R., Bettegowda, C., Chang, K., Li, R.J., Fakhry, C., Xie, T.-X., Zhang, J., Wang, J., Zhang, N., El-Naggar, A.K., Jasser, S.A., Weinstein, J.N., Treviño, L., Drummond, J.A., Muzny, D.M., Wu, Y., Wood, L.D., Hruban, R.H., Westra, W.H., Koch, W.M., Califano, J.A., Gibbs, R.A., Sidransky, S., Vogelstein, B., Velculescu, V.E., Papadopoulos, N., Wheeler, D.A., Kinzler, K.W., Myers, J.N. Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1. Science, 333:1154-1157, 2011. PMCID: PMC3162986.

Kinde, I., Wu, J., Papadopoulous, N., Kinzler, K.W. and Vogelstein, B. Detection and quantification of rare mutations with massively parallel sequencing. Proceedings of the National Academy of Sciences, U.S.A. 108:9530-9535, 2011. PMC3111315.

Jiao, Y., Shi, C., Edil, B.H., de Wilde, R.F., Klimstra, D.S., Maitra, A., Schulick, R.D., Tang, L.H., Wolfgang, C.L., Choti, M.A., Velculescu, V.E., Diaz, L.A. Jr., Vogelstein, B., Kinzler, K.W., Hruban, R.H. and Papadopoulos, N. DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors. Science, 331:1199-1203, 2011. PMC3144496.

Yan, H., Parsons, W., Jin, G., McLendon, R., Rasheed, A.B., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G.J., Friedman, H., Friedman, A., Reardon, D., Herndon, J., Kinzler, K.W., Velculescu, V.E., Vogelstein, B., and Bigner, D.D. (2009). IDH1 and IDH2 Mutations in Gliomas. NEJM. 360, 765-773.

Parmigiani, G., Boca, S., Lin, J., Kinzler, K.W., Velculescu, V., and Vogelstein, B. (2009). Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 93, 17-21.

He, Y., Vogelstein, B., Velculescu, V.E., Papadopoulos, N. and Kinzler, K.W. The Antisense Transcriptomes of Human Cells.  Science 322: 1855-1857, 2008.

Parsons, D.W., Jones, S., Zhang, X., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.M., Gallia, G.L., Olivi, A., McLendon, R., Rasheed, B.A., Keir, S., Nikolskaya, T., Nikolsky, Y., Busam, D.A., Tekleab, H., Diaz, L.A., Jr., Hartigan, J., Smith, D.R., Strausberg, R.L., Marie, S.K., Shinjo, S.M., Yan, H., Riggins, G.J., Bigner, D.D., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V.E., and Kinzler, K.W. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812.

Jones, S., Zhang, X., Parsons, D.W., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S.M., Fu, B., Lin, M.T., Calhoun, E.S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D.R., Hidalgo, M., Leach, S.D., Klein, A.P., Jaffee, E.M., Goggins, M., Maitra, A., Iacobuzio-Donahue, C., Eshleman, J.R., Kern, S.E., Hruban, R.H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V.E. and Kinzler, K.W.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses.  Science 321: 1801-1806, 2008.

Wood, L.D., Parsons, D.W., Jones, S., Lin, J., Sjöblom, T., Leary, R,J., Shen, D., Boca, S.M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T.,  Nikolsky, T., Karchin, R., Wilson, P.A., Kaminker, J.A., Zhang, Z., Croshaw, R., Willis, J.,  Dawson, D., Shipitsin, M., Willson, J.K.V., Sukumar, S., Polyak, K., Park, B.H., Pethiyagoda, C.L., Pant, P.V.K., Ballinger, D.G., Sparks, A.B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz,S.D., Parmigiani, G., Kinzler, K.W., Velculescu, V.E. and Vogelstein, B.  The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113, 2007.

 
Joomla Templates by Joomlashack