David Schlessinger, M.D.
National Institute of Aging
Contact Information
Triad Technology Center, Bayview Campus
Phone: 410-558-8337
Fax: 410-558-8331
E-mail:
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Research Interests
Aging, Development, Quantitative Trait Genetics
The Laboratory Projects study embryonic and developmental events critical for the aging of specialized mammalian cells.
Premature ovarian failure (POF). We identified a “winged helix” transcription factor, FOXL2, that is mutated to cause POF. A mouse knockout model shows that FOXL2 is involved in ovary formation and in the maintenance of female sex determination.
Skin appendage formation. Teeth, hair follicles and sebaceous and sweat glands are defective in patients with X-linked anhidrotic ectodermal dysplasia. We characterize the developmental course of the anomalies affecting the experimental mouse model.
Population-based study of genetic risk factors. In the founder Sardinian population, genes associated with obesity, height, lipids, uric acid, TSH, and HbF have been found.
Selected Publications
- Pilia, G., et al., PLoS Genetics. 2: e132, 2006.
- Cui, C.Y., et al., PNAS. Vol. 103: 9142-9147, 2006.
- Ottolenghi, C., et al., BioEssays. 29:15-25, 2006.
- Scuteri, A., et al., PLoS Genetics, July 2007, Volume 3, Issue 7.
- Cui, C.Y., et al., Human Molecular Genetics (in press, 2007).
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