vogelstein-b

Bert Vogelstein, M.D.

Clayton Professor of Oncology and Pathology
Investigator, Howard Hughes Medical Institute
Director, Ludwig Center for Cancer Genetics & Therapeutics
The Johns Hopkins Kimmel Cancer Center

Contact Information

Cancer Research Building Room 589
1650 Orleans St.
Baltimore, MD 21287
410-955-8878
410-955-0548 (Fax)
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Research Interests

Molecular Genetics of Human Cancer

It has long been hypothesized that genetic alterations are responsible for cancer. In the last two decades, this hypothesis has been verified by the discovery of genes which, when mutated, directly contribute to tumor initiation and progression.

Colorectal tumors provide a particularly good example of the relationship between such genes and a common human cancer. Studies in our laboratory have identified a series of genetic alterations which, in concert, convert a normal epithelial cell to a malignant one. These genetic alterations affect a specific subset of oncogenes and tumor suppressor genes. The goals of our current research include the following:

  • Identification of other genes which, when mutated, contribute to human tumorigenesis.
  • Delineation of the pathways through which these genes act.
  • Development of targeted therapies based on this knowledge.
  • Development of new diagnostic approaches based on the genes responsible for neoplasia.

Selected Publications

Vogelstein B, Kinzler KW.  Cancer genes and the pathways they control.  Nat Med. 2004 Aug;10(8):789-99. Review. PMID: 15286780

Cheong I, Huang X, Bettegowda C, Diaz LA Jr, Kinzler KW, Zhou S, Vogelstein B.  A bacterial protein enhances the release and efficacy of liposomal cancer drugs.  Science. 2006 Nov 24;314(5803):1308-11.  PMID: 17124324

Diehl F, Li M, Dressman D, He Y, Shen D, Szabo S, Diaz LA Jr, Goodman SN, David KA, Juhl H, Kinzler KW, Vogelstein B.  Detection and quantification of mutations in the plasma of patients with colorectal tumors.  Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16368-73. Epub 2005 Oct 28.  PMID: 16258065

Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE.  Mutant PIK3CA promotes cell growth and invasion of human cancer cells.  Cancer Cell. 2005 Jun;7(6):561-73.  PMID: 15950905

Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.  The consensus coding sequences of human breast and colorectal cancers.  Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.  PMID: 16959974

Wood, L.D., Parsons, D.W., Jones, S., Lin, J., Sjöblom, T., Leary, R,J., Shen, D., Boca, S.M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T.,  Nikolsky, Y., Karchin, R., Wilson, P.A., Kaminker, J.A., Zhang, Z., Croshaw, R., Willis, J.,  Dawson, D., Shipitsin, M., Willson, J.K.V., Sukumar, S., Polyak, K., Park, B.H., Pethiyagoda, C.L., Pant, P.V.K., Ballinger, D.G., Sparks, A.B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz,S.D., Parmigiani, G., Kinzler, K.W., Velculescu, V.E. and Vogelstein, B.  The genomic landscapes of human breast and colorectal cancers. Science 318:1108-1113, 2007.
 
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