Andrew McCallion, Ph.D.Image

Assistant Professor of Comparative Medicine and Institute of Genetic Medicine

Contact Information

Room 449, Broadway Research Building
443-287-5624; 410-502-7533
410-614-8600 (Fax)
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Link to Dr. McCallion's Lab Page

Link to McCallion Lab Projects

Research Interests

Gene regulation is the framework on which vertebrate cellular diversity is built. The substantial cellular diversity that characterizes complex integrated cell populations, such as the human central nervous system, must therefore require immense regulatory complexity. Similalry the cells comprising the embryonic neural crest, a populations which contributes craniofacial cartilage and bone, pigment cells of the skin and hair, neuroendocrine cells and the entire peripheral nervous system to the vertebrate embryo must face similar challenges in choosing the correct fate. These cells go awry in a wide array of human disorders like Parkinson's Disease, Hirschsprung Disease, Psychiatric disorders and Melanoma, and comprise the focus of our efforts.


Take a look at our lab website (link above) and some of our recent papers to see how we approach these fascinating problems.

Selected Publications

  • Antonellis A., Huynh, J., Lee-Lin, S., Vinton, RM., Renaud, G., Loftus, SK., Elliot, Wolfsberg, TG., Green, ED., McCallion, A.S.# and Pavan W.J. Identification Of Neural Crest And Glial Enhancers At The Mouse Sox10 Locus Through Transgenesis In Zebrafish. PLoS Genet. 2008, 4; 9. (#, Corresponding author)
  • McGaughey, D.M., Vinton, R.M., Huynh, J., Al-Saif, A., Beer, M., and McCallion, A.S. Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome Res. 2008 Feb;18(2):252-60.
  • Fisher, S., Grice, E.A., Vinton, R.., Bessling, S.L., Urasaki, A., Kawakami, K. and McCallion, A.S. (2006) Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish. Nature protocols 1, 1297-1305.
  • Fisher S, Grice EA, Vinton RM, Bessling SL and McCallion AS. (2006) Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity. Science. 2006 Mar 23; [Epub ahead of print]
  • Grice EA, Rochelle ES, Green ED, Chakravarti A, McCallion AS. (2005) Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer. Hum Mol Genet. 14 (24)
  • Sproat-Emison, E.E.,* McCallion, A.S.,* Kashuk, C.S., Bush, R.T., Grice, E., Lin, S., Portnoy, M.E., NISC Comparative Sequencing Program, Cutler, D.J., Green, E.D. and Chakravarti, A. (2005) A common, sex-dependent mutation in a putative RET enhancer underlies Hirschsprung disease susceptibility. Nature, 434 (7035): 857-63. (*, Authors contributed equally).
Book Chapters
  • Grice, E.A. and McCallion, A.S.  Genomic dissection of RET signaling in human disease. Signal Transduction: A Systems Biology Approach. Pandey; 1st edition, (2007) Humana Press, New Jersey, In Press.
  • Chakravarti, A., McCallion, A.S. and Lyonnet, S. (2000, revised 2003). Hirschsprung Disease. Chapter 251 in, The metabolic and molecular bases of inherited disease. Scriver, Beaudet, Valle and Sly; 8th edition, McGraw-Hill, New York.
  • McCallion, A.S., Chakravarti, A. (2004) RET, Hirschsprung disease and multiple endocrine neoplasia type 2. In Inborn Errors of Development. Editors Epstein, C., Erickson, R., and Wynshaw-Boris, A. Oxford University Press (San Francisco).
 
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